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Because response and tolerability vary, clinician-guided dosing and patient education are essential to ensure appropriate use, manage potential side effects, and establish realistic expectations for treatment outcomes

doi: 10.1210/endrev/bnaa026 68

Blood sampling Rats in the diestrus phase were anesthetized using intraperitoneal injections of Ketamine (50 mg/kg) and Xylazine (5 mg/kg) and blood samples were obtained via cardiac puncture